The starting point of acne formation is an increase in the sebum amounts secreted, as well as a change in the sebum composition in a way that makes it tending to form a clog in skin pores. Most of the currently used methods of treatment of acne favors increased sebum formation, as a part of accelerated body fat metabolism.
Most of them aim at producing a new skin after removing the old disfigured one. The new skin requires a lot of lipids that will be incorporated in the membranes of the newly formed cells. The cell membranes basically needs phospholipids, triglycerides, sphingolipids and cholesterol.
Synthesis of these lipids calls for activation of enzymes participating in biosynthesis of fat. Many enzymes has more than one spacial configuration, each of which has a different level of enzyme activity.
This effect is clear when we consider using scrubs to exfoliate the skin. The aim of this technique is to remove the dead skin cells to reveal newly formed epidermal cells. The cornified cell layers that are affected by exfoliation ranges from 10 to 30 layers. Decreasing this number of layers (thickness of epidermis), activates the germinative cells to produce keratin cells more rapidly to restore the epithelium to its normal condition.
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