How To Reduce Hair Fall Induced by Pantothenic Acid High Doses

I got this comment on the hub Acne Cure Guarantee : Coenzyme A - Pantethine concerning how one of my readers who used Pantethine and L-Cysteine to reduce hair fall caused by high doses of Pantothenic acid (10 grams/day).

"Darragh

Hi everyone,
Thank you for the information elqalatawy i'll keep taking cysteine hopefully the hair loss will stop after a few months its not really bad just makes me paranoid, too everyone else i wish i had of took Pathethine first instead of PA (10G). PA did work the fist time but not the second time which is strange and i got hairloss the second time so was a double bummer.. I think maybe because i had no cysteine left in my system that's a total guess but it makes sense cause you need cysteine to makeup co-enzyme and plus your hair needs its.

 Wini im taking 4 capsules a day 1800mg (450mg capsules) im gonna try half this in a couple of weeks its just i want my skin to be perfect before i drop down so i'll know whats my ideal dose if i get acne again.. my skin is perfect at the moment nose still a bit oily but 99% better than before(i use to get super oily)

The first two weeks i took Panthethine nothing happened to be honest i think i was more oily than the third week got a huge breakout was horrible(spots in places never got before) then the 4th week face was clear it was honestly like a light switch the way it works it didnt make oil less and less a day which you think it would it was honestly like an overnight light switch.. the night before it really happened i got really dry lips there kinda gone now which meant something did happen in my body that night..

everyone is going to be different with this stuff i would start off at 900mg for two weeks than if nothing happens like me double it as soon as i doubled it i got the horrible breakout but that's when it really started to work.. Thank You good luck everyone"

Why Does Your Current Acne Treatment Never Stop

Have you ever tried to stop your chosen treatment of acne? Don't you see that the condition which seemed to improve with the treatment, now worsened and may be aggravated?

It is the basic concept behind almost all acne treatments that is responsible for that. This concept that makes you skinned every day to have a new skin. Removal of the old skin removes the old sebum, yet the new formed skin should have its own sebum, and it quickly produces it. 

Don't you read.. "Use a face wash or scrub at least once daily to remove excess oil and dead skin cells from the skin.. Use a toner to remove even more oil..  Once a week, apply this mask or that mask on your affected areas?" ..

Don't you also read that.. "these techniques take only a few minutes a day and should be done REGULARLY?". Isn't that regimen that you follow now?..

It is this basic concept that makes acne treatment never stops:
"Remove the old oil marinated skin and get a new one and it will have less oil.. don't let your body stop making new skin and new sebum all the time"...

Mind you, formation of new skin and new sebum requires synthesis of a great amount of fat like glycerides, phosopholipids, cholesterol, wax, squalene.. etc and this puts an additive burden on fat metabolism.

This is why many people find their acne is worsened and aggravated if they stop their regular regimens.. They now have a higher set up point of fat metabolism, where only fat synthesis is accelerated due to activation of its concerned battery of enzymes.


Nobody thinks to overcome a temporary metabolic condition that caused oil over-secretion in the first place, to dry-up oil from inside out.. Instead, they start a process of skin removal that never ends. You are skinned every day and forever!

Looking at what you regularly use now to treat acne will make the picture more clear..


- Alpha Hydroxy Acids (AHAs):
AHAs are a group of organic carboxylic compounds. AHAs most commonly used in cosmetic applications are typically derived from food products including..
Glycolic acid (from sugar cane), Lactic acid (from sour milk), Malic acid (from apples), Citric acid (from citrus fruits) and Tartaric acid (from grape wine).

AHAs have a profound effect on keratinization; which is clinically detectable by the formation of a new superficial cornified epidermal layer.

It appears that AHAs accelerate this formation through diminished cellular cohesion between cornified cells, and their basement membrane.

In low concentrations that are sold to consumers (5 - 10%) , they remove the top layers of dead skin cells by reducing cell adhesion in this layer. This action promotes exfoliation of the outermost layer of the skin.

The skin produces new cells to replace the removed layers of cells. Fat synthesis is activated to build cell membrane lipids.

They are better used for treating skin wrinkled and aged by sunlight.


- Beta Hydroxy Acids:
The only known beta hydroxy acid is Salicylic acid which is used in concentrations from 0.5 to 2%. There is only one difference between alpha and beta hydroxy acids, the former is water soluble while the later is lipid soluble.

This means that beta hydroxy acid is able to penetrate into the pore which contains sebum and remove the dead skin cells that are built up inside the pore. This is why Salicylic acid is commonly used for oily skin.

It removes more layers of your skin and this why it increases sun sensitivity by 50%, it makes the skin more susceptible to sun UV rays.

Fat synthesis is activated to build fat membrane lipids, needed for formation of new cells in place of the removed ones.



- Benzoyl Peroxide:
Benzoyl peroxide is available as cream, gel, lotion and wash at concentrations of 2.5 %, 5 % and 10 %. It has an antiseptic, oxidative and anti-inflammatory effects.

Dryness, irritation and contact dermatitis are the major drawbacks of using Benzoyl Peroxide on the skin, although some of the symptoms like burning, itching, peeling and possibly swelling are very rare.

Benzoyl Peroxide dissociates Oxygen radicals which reacts with the aero-intolerant Propinibacterium acnes bacteria, removing them all.

It is these radicals that may change the cellular environment (Redox potential), allowing some molecules to react non-enzymically and deprive the cells from some metabolites, that they need to proceed normally.

Can you stop using Benzoyl Peroxide?


Hormone Therapy:
Oral contraceptive that contain derivatives of estrogens and progesterone that are present normally in women's bodies, are sometimes used to control acne lesions in women.

They increase the amount of a protein that binds sex hormones including testosterone, which is known to stimulate the production of sebum in both males and females, thus decreasing its free amount in the blood.

Estrogens increase both epinephrine and insulin, and both can cause accumulation of fat in sebaceous glands
(refer to chapter 4).

The initial reduction in free testosterone may reduce sebum secretion, yet the long run use of hormones has many other effects, including effects on hormones and enzymes that affect lipids, set aside systemic side effects.


- Retinoids:
The Retinoids are a class of chemical compounds that are related chemically to vitamin A. Retinoids are used in medicine, primarily due to the way they regulate epithelial cell growth.

Common skin conditions treated by Retinoids include acne and psoriasis. Isotretinoin is considered the only known possible cure of acne in some patients.

Chronic overdose causes an increased liability of biological membranes and of the outer layer of the skin to peel. Use of Retinoids induces a change in the way epithelial cells proceed normally.


In conclusion, most of the commonly used acne treatments now either, accelerates renewal of skin cells or changes the way the skin cells behave, both deprive them from crucial tools they need to fight acne.

This is why you observe improvement during the first few days of implementing a new treatment, and then you observe worsening of the condition accompanied with even new symptoms you did not recognize before.

The new treatment made your skin more hungry for the proper tools to fight acne.

Read More to Know How Can You Stop Treatment of Acne after Its Elimination

Pantethine - The Best Alternative of High Doses 0f Pantothenic Acid

Pantethine іѕ a dietary supplement thаt іs converted іntо tо vitamin B (pantothenic acid) іn thе body.

Pantethine іѕ uѕеd fоr lowering cholesterol, preventing inflammation, boosting thе activity оf thе immune system, treating аn inherited condition called cystinosis, treating gastrointestinal (GI) diseases, аnd improving athletic performance.

It іѕ аlsо uѕed fоr improving energy, lowering thе risk оf heart attack аnd stroke, improving adrenal function, protecting аgаinѕt mental аnd physical stress, аnd preventing allergy symptoms іn people who аrе allergic tо formaldehyde.

Hоw dоes іt work?
Pantethine mіght increase thе concentrations оf Coenzyme-A thаt mаy lоwer blood cholesterol аnd triglycerides.

It іѕ effective іn lowering blood fats ѕuch аѕ cholesterol аnd triglycerides, but оnly modestly. While nоt аll research findings agree, tаkіng pantethine mіght slightly lоwer triglycerides, total cholesterol, аnd “bad” low-density lipoprotein (LDL) cholesterol; аs well аѕ raise “good” high-density lipoprotein (HDL) cholesterol. Pantethine аlѕo appears tо correct blood fat problems thаt оftеn occur іn kidney failure patients who аrе undergoing hemodialysis.


Thеrе іѕ аn insufficient Evidence thаt іt mаy :
- Treat cystinosis, аn inherited disease. Early research suggests thаt pantethine mіght bе beneficial fоr cystinosis.
- Improve athletic performance.
- Reduce risk оf heart аnd circulatory disease.
- Improve function оf thе adrenal gland.
- Prevent allergy symptoms іn people allergic tо formaldehyde.

Tаkіng pantethine appears tо bе safe fоr mоst people fоr up tо a year. Pantethine cаn cаuse nausea, diarrhea, аnd stomach discomfort.

Special Precautions & Warnings:
Pregnancy аnd breast-feeding:
Nоt еnоugh іs knоwn аbout thе uѕe оf pantethine durіng pregnancy аnd breast-feeding. Stay оn thе safe side аnd avoid uѕе
Bleeding disorders:
Thеre іs ѕome evidence thаt pantethine cаn slow blood clotting, ѕo ѕome healthcare providers worry thаt pantethine mіght increase thе risk оf severe bleeding іn patients with bleeding disorders. If you hаvе a bleeding disorder, gеt your healthcare provider’s advice bеfore starting pantethine.

Surgery:
Pantethine mіght slow blood clotting. Thеre іs a concern thаt іt mіght increase thе risk оf extra bleeding durіng аnd аftеr surgery. Stop uѕing pantethine аt lеast 2 weeks bеfоrе a scheduled surgery.


Pantethine Interactions :

Medications thаt slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with PANTETHINE

Pantethine mіght slow blood clotting. Tаking pantethine аlong with medications thаt аlѕо slow clotting mіght increase thе chances оf bruising аnd bleeding.

Sоme medications thаt slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, оthеrs ibuprofen (Advil, Motrin, оthers naproxen (Anaprox, Naprosyn, оthеrs dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), аnd оthеrs
Fоr treating tоо much fat іn thе blood (hyperlipoproteinemia): 300 mg оf pantethine 3 tо 4 times daily.

Use of Pantethine to Treat Acne :
Fеw people аre uѕing oral Pantethine tо treat acne. Thеy report good effect оn acne, but ѕоme оf thеm аrе uѕing іt іn combination with оther supplements.

Thе metabolic fate оf аn oral dose оf pantethine іn humans hаs nоt bееn clеаrly dеscribed At lеаst part оf іt іs absorbed unchanged, аnd аnother part іs
hydrolyzed іn thе intestinal mucosa cells іnto pantothenic acid.

Itѕ recommended dose іs bеtwееn 900 tо 1200 mg, yet ѕоme people report thаt thе optimal dose fоr clarifying acne іѕ 2.5 gram pеr day.

It hаѕ fеwer side effects thаn оther amino acids thаt mаy bе uѕеd fоr thіѕ purpose, еg Cysteine induces drying оf thе skin аnd lips.


Thе feedback оf uѕіng oral Pantethine tо treat acne іѕ very good, аnd hеrе аrе ѕоme examples:

"Yes I hаvе bеen tаkіng panthethine ѕіnce December 24, 2011. I thіnk 900 mgs оf panthethine аlonе іѕ еnоugh tо kееp acne аt bay"


"Thе results frоm thе b5 аnd cysteine pluѕ pantethine hаve оnly gоttеn bеttеr аnd thе stubborn spot hаs nоw gоnе аwаy I аm nоw clear!"


"It ѕеems tо juѕt bе a matter оf tаkіng еnough pantethine tо eliminate acne, which mаy differ ѕоme frоm person tо person. Dоes thаt ѕeem аbоut rіght tо you? It ѕhould rеally bе called thе acne cure, nоt pantethine, іf you аsk mе."

"I аm uѕing jarrow formulas pantethine, аnd I аm currеntly tаkіng 5 X 450mg pills a day. I started with twо a day аnd slowly worked up I dіd nоt start tо ѕеe noticeable results untіl I reached 5 a day."

Read how to use Pantethine to get rid of acne:
How To Get Rid of Acne Overnight and Forever

Yeast as an Alternative to Treat Acne

The best way to treat acne or any other ailment is to encompass its metabolism in the general body metabolism. Yeast (Brewers' or Supplementary) contains almost all the ingredients required to boost acne metabolism in the right direction.

Here is the content of one of Brewer's Yeast brands:

Calories .................................. 50
Calories from fat ................... <5
Total Fat ................................. 0.5 G
Total Carbohydrate................ 5 G
L-Histidine ............................. 200 MG
L-Lysine ................................. 575 MG
Papain .............................. .... 25 MG
Bromelain ..............................  50 MG
PABA .....................................  80 MG
Inositol .................................... 100 MG
Choline ................................... 160 MG
Sodium ...................................  10 MG
L-Proline ................................. 335 MG
Zinc .........................................   4 MG
Magnesium ............................ 250 MG
Iodine ...................................... 120 MCG
Potassium .............................. 395 MG
L-Cystine ................................  95 MG
L-Tryptophan ..........................  73 MG
L-Phenylalanine ..................... 300 MG
L-Tyrosine .............................. 315 MG
L-Leucine ............................... 560 MG
L-Isoleucine ............................ 355 MG
L-Threonine ............................ 350 MG
L-Valine ................................... 450 MG
L-Arginine ............................... 545 MG
L-Glutamic Acid ..................... 1280 MG
Glycine .................................... 345 MG
L-Alanine ................................ 535 MG
Selenium ................................  25 MCG
L-Serine ................................. 340 MG
Phosphorous ......................... 177 MG
L-Aspartic Acid ..................... 785 MG
L-Methionine .......................... 100 MG
Sugars ....................................   1 G
Chromium ............................... 100 MCG
Iron ..........................................  10 MG
Protein ....................................   6 G
Thiamin ...................................  16 MG
Pantothenic Acid ...................  80 MG
Niacin ..................................... 160 MG
Vitamin B6 .............................  16 MG
Folic Acid ............................... 200 MCG
Vitamin B12............................  25 MCG
Biotin ...................................... 100 MCG
Vitamin B2 .............................  16 MG
Calcium .................................. 500 MG

Yeast contains most of the amino acids including the sulfur containing amino acids, vitamins specially pantothenic acid, minerals specially zinc and enzymes like papain and bromelain.

Yeast - thanks to its contents - resembles a natural substance that seems to be particularly designed to treat acne. When introduced into the body, yeast contents direct metabolism in the way of getting rid of excess oil through converting it into energy.

The only drawback of use of yeast for that purpose is that its useful contents, are sometimes not sufficient to correct the large metabolic changes brought about by the modern lifestyle.

Yeast can be used to treat mild conditions of acne, or to keep acne at bay in a clear skin. It can be used orally or included in homemade masks.

Look Inside "How to Get Rid of Acne Overnight and Forever" Book

Today I will let you look inside my new book "How To Get Rid of Acne Overnight and Forever".
Since the material the book encloses is new, I preferred to start from the very beginning ; the introduction, as it lays the ground for reading the information inside the book.

                                                            Introduction

                                                 The Real Cause of Acne

"Get Rid of Acne Overnight?.. and forever?"

Is it possible to get rid of acne vulgaris overnight? Yes, the body does not take more than one night to clear acne when we help it to proceed in the right track.

Forever? Yes, after you clear your acne you will watch your skin and be ready to prevent acne formation right from the start. Moreover you will define exactly what caused acne breakouts.

So why I am so sure?

Here is messages sent by one of my readers :

'I have never been this clear before ever since I started getting acne and this is the only thing I have ever tried that can actually work "too well".'

"I can now report Success!!! The stubborn spot has now gone away. I am now clear!"

Here is other messages from a different reader :

["skin getting clearer. No new papules!!! No side effects except dried margins of upper and lower lips which I'm controlling with lip balms and less sleep and now I wake up early easily!"

"Update: redness is almost gone. No new acne even after having desserts I couldn't enjoy before. Old pimples are in resolution. Overall, I feel my face is not breaking anymore."]


Here is another message from a third reader :

"One thing I forgot to say was thank you to elqalatawy for the quality of info in this thread. This is the sort of thing that should have been provided years ago but no one cared."

These messages and many others were sent to me, after using an older regimen that I have filtered, to make it simpler and more convenient to produce prompt results.

What makes you feel more comfortable about the new treatment, is to compare the strategy it uses to the strategy that is used by all other treatments.

Scanning all the products out there that treat acne, we will find that they do not deal with the underlying cause of acne, rather they deal with its symptoms.

The acne products are categorized into 2 categories, a individual product category which includes products treating individual symptoms like, whiteheads, blackheads, pimples, pustules, papules...etc.

Or the other group category that points to the way you will get the treatment like, home remedies, OTC products, prescription drugs...etc, and all treat symptoms.

ALL of them either have incomplete results, or they have side effects. You have to use them for years or until you get serious side effects that require stopping the treatment. When you stop the treatment the case would be worse than when you started up.

It is not the best way that you use safe remedies that have incomplete results, or do not have even results for all individuals.

After all, they are empirical ways that helped some people, in some communities and in some times, with all what this involves of changed environments and personal habits.


Perhaps you use some OTC products that relieves some symptoms, but this keeps you using them endlessly, keeps you alert to get new information about something seems to be used forever, as well as it keeps you allocating some of your income for buying them.

In many cases, they fail to control acne.


It is not convenient either to listen to some advices on how you can prevent acne, by living a strange style of life that involves a lot of restrictions like, banning some foods, sparingly using makeup or perfumes, keeping away from sun exposure, or chilling while you are frustrated!.


It is not also wise to wait until you need a prescription drug like Retinoic acid derivatives, which change the way your skin cells act as they work there in the cell nucleus.

They have serious side effects and when stopped, the condition may be aggravated more than the very beginning.


You may have tried one or more of these approaches, in fact this is part of the problem, because it may take acne to unpredictable new skin traits, that change the way metabolism reacts to the changed situations that produce acne.


Unless you cure acne overnight then you treat it the wrong way. It is there in the machinery of your body and all what you have to do is to relieve the pressure they are submitted to.


You have to recognize where are your body strengths to use them to get rid of a small obstacle on its way.


So what am I talking about?

You may think that I will tell you to apply an ice pack, lemon juice, toothpaste or any other application to the affected areas to reduce the inflammation and redness, making the acne less visible.


Or you may be inclined to think that I will recommend that you detoxify your body, to get acne free by one of those magical detoxification plans that work non-specifically.


I am really talking about something you have never heard of before.

Yes, you read it right, you have never known of this information before. Even if you've read me here or there, the information here has never been published before.


Without the proposed hype about myself, I am a pharmacist that have practiced pharmacy for more than 30 years (having a little experience under my belt), and I have seen all types of treatments and known their results and all their effects.

I revised one product after another, and seen its therapeutic and side effects. As I am apt to Biochemistry, I always thought that there should be something that is better than all of that.

Something that encloses the acne metabolism within the normal metabolism to get rid of acne, EFFECTIVELY and SAFELY.


What is Missing You to Get Rid of Acne Forever?

People have never known the real cause of acne and they vaguely accused hormones, diet or stress to be the causes of acne, without looking at the whole picture of metabolism. How these factors affect metabolism.

All the suffering from acne and its treatments are caused by the associated opposite effects of its underlying cause..

"But what is the cause of acne and its opposite effects, and how acne is cured through them?"

You will ask..

In a moment...



                                                     Fat Metabolism

In short and condensed words (more detailed as we go through the book together), here is the thing:

Acne is caused by the inability of the body to accelerate the building-up and breaking-down of fat at the same time, and this in turn causes some surplus fat to be stored in the skin.

This stored fat contains among other constituents glycerides and fatty acids, which offer the nourishment for certain bacteria which multiplies and initiate an inflammatory process... and this later may lead to scar formation.

It is these glycerides and fatty acids that are the 'polymorphous' part in the whiteheads - which are continuously formed - that leads to transforming the bumps from a fatty environment to an aqueous environment...

the background of a microscopic life with all its problems to the skin.

Once you enhance fat metabolism through accelerating its opposite tracks (building up and breaking down) that are both under pressure, you will get rid of the unneeded fat and let the body builds other fat - it needs - its own required way at the same time.. and get rid of acne. 

This will also ensure the continuous disposal of whiteheads once they are formed, thus erasing the cornerstone of all acne forms and symptoms.


Without boosting the opposite pathways of fat metabolism, whiteheads will be continuously changed leading to blackheads, pimples, pustules, papules ... or scars, with all what it takes of suffering, embarrassment, frustrations and cost.

This may represent a social barrier for you, or it may
bring up problems that takes you to another level of expensive or risky practices, like prescription Retinoids, surgery, laser, dermabraison....etc

Boosting fat metabolism in both opposite directions sets you free to live the energetic stage of your life, merrily, happily, and peacefully without being imprisoned in the shameful, embarrassed and frustrated acne-problem personality.


I just want you to know that these are not just a bunch of bold statements merely posed for the sake of trying to be 'different and innovative'. In fact:

- I recommended this regimen for many clients of my private pharmacy with great success

- I present tips to some of my readers online and they are so thankful because of the results

- I am in the process of registering a topical formula of this treatment in my country

So you will realize that 'Boosting fat metabolism', is not a scientific jargon about acne, that is said everywhere to make you frightened to ask about complicated science, and leaving you armless facing acne.

In fact, as you will learn easily, that this is the ultimate solution of the problem of acne.

Moreover, you will realize that it is unprecedented way of treatment of acne, and that it has the potential to make you acne free forever, if only you allow it to.
 
You are lucky enough to read this book, because you are a few minutes away from learning a new skincare regimen secrets, that will stay with you for life, prevent acne formation and gets you a younger smooth skin.

Moreover, you will be the expert that family and friends consult you, about the proper skincare types. After you learn how to prepare the best acne treatment, you can even sell it.


If you have searched for information about how to get rid of whiteheads or blackheads to prevent acne, because you have the gut feeling that everything starts with them, you are right and you will be rewarded by reading this book.

Everything I will present to you in the next few chapters is based on accumulated practical experience, of implementing ideas that are based on solid science. I promise that I won't hold anything back.



                    Before we start..


You probably got into this from either of the following situations:

- You may be just starting your 'acne treatment', you read about or listen to many 'words of mouth' about this product or that product .. and you don't know really where to start

- Or you are one of those who doubt all this commercial hype that is not based on documented facts, and you believe that remedies are the best hoping that this 'last one' you are reading now will complement your 'previous one'...

- And may be you suffer side effects of one or another acne treatment...and you're completely frustrated because after stopping your treatment you've got worse acne..


You may have tried lots of things already... but nothing helps... In turn, you're angry, sad, desperate of finding a proper acne treatment or cure.


Either way, I've got good news for you :

Whatever the situation you come from, you are in the right place.

You are about to discover the whole thing and take up knowledge that goes way beyond most currently prevailing acne treatments, which for many have never ended and/or yielded disappointing results.

In the next few chapters, I will guide you step-by-step into a complete understanding of how acne is formed, and consequently how it is treated , cured and prevented.

I will be able to clearly explain to you:
The what...
The why...
And most important of all: the how...

of boosting your fat metabolism the right way and getting rid of acne, to live your life the way you like. As such, this is not a bunch of vague statements of probabilities.

Instead, you'll have an acne stanza that will teach you everything about acne including, a complete practical way of treatment that is guaranteed to blow your mind.

So brace yourself to get all the details, with all the clarity you need! You're going to learn the whole story of how to keep acne away in the clearest way you'll ever come across.


Now you may ask how can I offer you this complete solution to acne for that price, while we all know that you pay hundreds or thousands of dollars for an incomplete endless regimens..

well, in fact I want to present a powerful product for a price that is affordable to anyone , to get readers thrilled about my writing. I like to entice fans of holistic treatments.

Just hop on... come along... and "let's get rid of acne forever"!

How To Get Rid of Acne Overnight and Forever

Sebaceous Gland Lipids and Acne

Thе principal activity оf mature sebaceous glands іѕ producing аnd secreting sebum, which іs a complex mixture оf lipids.


In human sebum thеre аre unique lipids, ѕuch аs squalene аnd wax esters nоt fоund аnywhеrе еlѕe іn thе body nоr аmong thе epidermal surface lipids. Mоrеover thеy correspond tо major components supplying thе skin with protection.


Increased sebum secretion іѕ considered, аmong аll features, thе major оnе involved іn thе pathophysiology оf acne. Alоng with increased sebum secretion rate, qualitative аnd quantitative modifications оf sebum аrе lіkely tо occur іn thіѕ pathology.


Thе pathways leading tо thе formation оf lipids, which аrе typically sebaceous, ѕuch аѕ branched fatty acids аnd unsaturated fatty acids (specially Linoleic acid), remain tо bе elucidated.  


Nеw insights rеgardіng modifications іn thе amount, composition аnd arrangement оf fatty acids assembled іn complex lipids оf sebum cоuld improve оur knowledge оn thе function оf sebum аnd оn thе role оf alteration оf sebum organization іn thе pathogenesis оf acne аnd оf dіffеrent sebaceous gland disorders.


At lеast we nоw knоw thаt аny factor thаt increases sebum secretion lіkе regeneration оf nеw skin cells), would predisposes thе skin tо formation оf nеw acne.

Acne and Linoleic Acid

According to Journal of Dermatoendocrinology, published in PubMed:

[ Decreased concentration of Linoleic acid has been observed in skin surface lipids of acne patients. In particular, its level has been found significantly reduced in wax esters making it reasonable to assume that Linoleic acid is directly involved in the sebaceous lipid synthesis.


Moreover, experimental data suggest that it is incorporated in epidermal lipids of the infundibulum. In experimental models, Linoleic acid is preferentially transformed into two carbons precursors in the sebaceous gland by entering the β-oxidation reaction at the acylside chain, which yields to Acetyl-CoA.

The latter product feeds the biosynthetic pathway leading to Squalene and wax esters synthesis. It seems that β-oxidation of Linoleic acid is specific of sebocytes and that it is correlated with their differentiation.

A diminished amount of Linoleic acid has been proposed as a factor predisposing to comedones formation. Moreover, low level of Linoleic acid also produces impairment of the epidermal barrier function, which might account for increased permeability of comedonal wall to inflammatory substances.]


Linoleic acid (LA) іѕ аn unsaturated n-6 fatty acid. It іs a colorless liquid аt room temperature. In physiological literature, іt hаѕ a lipid number оf 18:2(n-6). Chemically, Linoleic acid іs a carboxylic acid with аn 18-carbon chain аnd twо cis double bonds; thе fіrst double bond іs located аt thе sixth carbon frоm thе methyl еnd
Linoleic acid belongs tо оnе оf thе twо families оf essential fatty acids thаt humans аnd animals muѕt ingest fоr good health, bеcausе thе body requires thеm fоr various biological processes, but cаnnоt synthesize thеm frоm оthеr food components.

Thе word "Linoleic" cоmеѕ frоm thе Greek word linon (flax). Oleic means оf relating tо оr derived frоm oil оr olive" оr оf оr relating tо oleic acid" bеcause saturating thе n-6 double bond produces Oleic acid.

It іs fоund іn thе lipids оf cell membranes. It іѕ abundant іn mаny vegetable oils, comprising оvеr hаlf by weight) оf poppy seed, safflower, sunflower, аnd corn oils.

A diet оnly deficient іn linoleate cаuѕeѕ mild skin scaling, hair loss, аnd poor wound healing іn rats. Hоwever achieving a deficiency іn linoleic acid іѕ nеarly impossible consuming аny normal diet аnd іs thuѕ nоt considered tо bе оf clinical concern.

Krebs Cycle and Acne

Wikipedia

Do you ask yourself what Krebs' cycle do to acne? In a minute..

Krebs, Citric acid or Tri-carboxylic acid cycle is the mechanism through which, the powerhouse of the cell (mitochondria) extracts Hydrogen present in the carbon backbone of foods, to be oxidized through a process called oxidative phosphorylation to produce high-energy molecules plus water, in all aerobic organisms that can not live without Oxygen.

The starting material of this cycle is Citric acid. It is a 6-carbon molecule that is produced by condensation of the 4-carbon molecule Oxaloacetate with the 2-carbon molecule Acetyl-Coenzyme A.

All the metabolites dealt with mitochondria can be exchanged with cytoplasm directly or indirectly, through permeases (antiporters) present in its inner membrane, so that it can take up substrates of oxidation and export energy rich products, as well as molecules needed for anabolism (biosynthesis) of the cell.

Coenzyme A is crucial for the activity of the mitochondria and for fat biosynthesis. During acne formation, both anabolism and catabolism (breakdown of metabolites to produce energy) are highly active, and the cell may decline producing energy in favor of fat biosynthesis in some tissues.

Adding Coenzyme A or its precursors to the system restores the cell ability to perform production of both energy and fat efficiently, resulting in prevention of acne formation. 

Nelly Furtado Acne - I'am Like A Bird

Nelly Furtado is a fabulous Canadian singer-songwriter, known for hit songs such as I'm Like a Bird and Say It Right.

Nelly Furtado usually looks fresh and stunning, however on this day she stepped out with some serious pimple action on her forehead.

Here is Nelly in a beautiful scene with birds singing " I'm Like A Bird".

Acne Best Treatments

Acne is made into a myth. Best treatments of acne are hindered by the pervasive sources of information out there regarding the causes of acne. Persistent myths prevent acne patients from seeking the right treatment.

Available acne treatments range from home remedies and masks, to supplements and prescription drugs. Home remedies are empirical treatments that may not suit all individuals.
Acne patients may lose their money and their hair using very high doses of supplements like vitamin B5, or as the least side effects of using a prescription like Accutane.

In fact, people who suffer acne or those who treat them, both deal with acne the wrong way although it is simpler than that. We all should know that whiteheads and blackheads in the skin are like Cerumen (ear wax) in the ear, which is produced by the sebaceous glands in part.
Acne converts into a disease when we lead the body to deal with it the wrong way. When the fatty bumps are infected, the body deals with them as an aggression that is fought by inflammation, which may lead to scar formation.

Acne is the result of increased fat synthesis (fat again?!!) and the body stores this fat in its assigned locations, that is the oil glands. The body does not react with fat clogs in the skin unless their content is changed to include bacteria or an allergen.

We do not need to lead the body to get a real disease, when we try to win the battle with acne which is not a real disease. The best treatment of acne is to remove the accumulated fat from inside out. It is to give the body the subsidiary tools  needed to "digest" this fat and burn it, and this the subject of another article.

Role of Hormones in Acne

Male and female hormones secretion triggers an acne flare. Both types of sex hormones are present in both sexes, their ratio in each sex is completely different from the other, and this is what makes all the differences between male and female.

One of the effects of male sex hormones (androgens) is to induce the sebaceous glands to secrete excessive amounts of oils that clog the skin pores. The relation between acne and androgen effect is not proportional, but the relation with synthesis of steroidal hormones is.

can we imagine that continuous injection of androgens will make an oil well in the skin?. An androgen is what causes hair growth in girls, but we can not make their hairs grow longer by giving them more androgens.

Acne is developed when the body is in the process of activated fat synthesis, to produce regulatory molecules (steroidal hormones), and it increases production and storage of sebum (oil) in the process. It should synthesize sebum anyway, and if there is some extra amounts they can be stored there in the oil glands.

If we can boost fat metabolism, then the body would be capable of burning the extra fat present in the oil glands, and thus clearing whiteheads, blackheads and pimples.

The one molecule that is used to start oxidation of fat (and carbohydrates) in the mitochondria, is Coenzyme A. The body recycles this pivotal molecule to enter intermediary molecules into the tricarboxylic acid (Krebs) cycle in the mitochondria (power house) to produce energy.  Coenzyme A is the molecule that starts fat synthesis as well.

The body makes Coenzyme A by combining, Vitamin B5, Cysteine (amino acid) and ATP (a high energy molecule). Normally, the body depends on the diet to obtain Vitamin B5 and Cysteine (or Methionine).

When the body is urged to synthesize increased amounts of steroidal hormones, Coenzyme A formed is shunted into the route of fat synthesis. Were there more Coenzyme A, the body will burn fat deposited in the sebaceous glands.

If we supply the body with supplementary amounts of the precursors of Coenzyme A, it will make more amounts to oxidize and burn fat stored in the oil glands. Consequently, you can take Vitamin B5 (or Pantethine) and Methionine (Cysteine). This is tried with success by many people as you can see here Acne Cure Guarantee

Acne Useful Facts

Memnoch636: Pantothenic Acid + Cystine - Acne Message Board - HealthBoards


I wrote these hubs The B5 New Acne Cure,Acne Cure Guarantee, Coenzyme A Supplement, Acne Laser Treatment Is Not The Perfect Solution about use of precursors of Coenzyme A to cure acne. Browsing the internet for some information about the trend, I found this thread and I found that it contains some crucial information. In PubMed.gov, it is mentioned that an exogenous supply of cysteine was needed to maintain maximal rates of protein and CoA synthesis. Keratin (protein) in hair needs cystine to be maintained healthy, and this could explain the negative effects of high doses of Pantothenic acid on hair.

Thus, Pantothenic acid depletes the body of the amino acid Cysteine, on scietific basis. 1 molecules of Cysteine is needed to form Coenzyme A, and 2 molecules of CYSTEINE are needed to form the amino acid CYSTINE in keratin.

The thread contains also the contents of Brewer's Yeast, it is really a goldmine for acne sufferers. It contains 80 mg of Pantothenic acid, 100 mg of L-Methionine, 95 mg of L-Cystine, and 100 mcg of Biotin.
It is also a rich source of other amino acids, minerals that are needed by the skin like manganese and magnesium, and trace elements like Selenium.

Now I can comfortably recommend that you can cure acne by combining Pantethine or Pantothenic acid with Methionine, and you may take Brewer's yeast supplement.

One final word, you should use these supplements during breakouts until they fade. If you plan to use them for a long period then you should consult your doctor. Long term use of high doses of these supplements may induce side effects, and some of them may be serious.